Protriptyline (hydrochloride)

CAT: 0804-HY-B0949-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0949-01Size:5 mg
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Description
Protriptyline hydrochloride is a potent tricyclic antidepressant (TCA) . Protriptyline hydrochloride inhibits AChE activity with an IC50 value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline hydrochloride can be used for the study of depression and Alzheimers disease[1][2][3].
CAS Number
[1225-55-4]
UNSPSC
12352005
Hazard Statement
H301, H312, H315, H319, H335
Target
Amyloid-β; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Protriptyline-hydrochloride.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13.[H]Cl
Molecular Formula
C19H22ClN
Molecular Weight
299.84
Precautions
H301, H312, H315, H319, H335
References & Citations
[1]Bansode SB, et, al. Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease. PLoS One. 2014 Aug 20;9 (8) :e105196.|[2]Chang HT, et, al. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015;35 (5) :429-34.|[3]Tiwari V, et, al. Protriptyline improves spatial memory and reduces oxidative damage by regulating NFκB-BDNF/CREB signaling axis in streptozotocin-induced rat model of Alzheimer's disease. Brain Res. 2021 Mar 1;1754:147261.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
AChE

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