Protriptyline (hydrochloride)

• Description :

  Protriptyline hydrochloride is a potent tricyclic antidepressant (TCA) . Protriptyline hydrochloride inhibits AChE activity with an IC50 value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline hydrochloride can be used for the study of depression and Alzheimers disease[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H312, H315, H319, H335

• Target :

  Amyloid-β; Cholinesterase (ChE)

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Protriptyline-hydrochloride.html

• Concentration :

  10mM

• Purity :

  99.91

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

• Smiles :

  CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13.[H]Cl

• Molecular Formula :

  C19H22ClN

• Molecular Weight :

  299.84

• Precautions :

  H301, H312, H315, H319, H335

• References & Citations :

  [1]Bansode SB, et, al. Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease. PLoS One. 2014 Aug 20;9 (8) :e105196.|[2]Chang HT, et, al. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015;35 (5) :429-34.|[3]Tiwari V, et, al. Protriptyline improves spatial memory and reduces oxidative damage by regulating NFκB-BDNF/CREB signaling axis in streptozotocin-induced rat model of Alzheimer's disease. Brain Res. 2021 Mar 1;1754:147261.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  AChE

• CAS Number :

  [1225-55-4]