Products for Research Use Only
RegisterLogin

Protriptyline

CAT: 0804-HY-B0949ASize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B0949ASize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Protriptyline is a potent tricyclic antidepressant (TCA) . Protriptyline inhibits AChE activity with an IC50 value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline can be used for the study of depression and Alzheimers disease[1][2][3].
CAS Number
438-60-8
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Amyloid-β; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/protriptyline.html
Solubility
10 mM in DMSO
Smiles
CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13
Molecular Formula
C19H21N
Molecular Weight
263.38
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Bansode SB, et, al. Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease. PLoS One. 2014 Aug 20;9 (8) :e105196.|[2]Chang HT, et, al. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015;35 (5) :429-34.|[3]Tiwari V, et, al. Protriptyline improves spatial memory and reduces oxidative damage by regulating NFκB-BDNF/CREB signaling axis in streptozotocin-induced rat model of Alzheimer's disease. Brain Res. 2021 Mar 1;1754:147261.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
AChE

Alternative Products

CatalogName
T60430-01Protriptyline
TRC-P838875-50MGProtriptyline Hydrochloride
AR-P03184-01Protriptyline-d3
MBS576143Protriptyline HCl
sc-20883110-Hydroxy Protriptyline
AR-P03183-01Protriptyline-d6
TMIH-0460-01Protriptyline-d3 Hydrochloride
AR-P03185-01Protriptyline-N-Oxide
CS-O-39068N-Nitroso Protriptyline
RM-P715001-01N-Nitroso-Protriptyline

Popular Products