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CXCR3 antibody

CAT: 0710-FNab09859Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09859Size:100 µg
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Background
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant) . Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716) .
Synonyms
C-X-C chemokine receptor type 3 (CXC-R3, CXCR-3) |CKR-L2|G protein-coupled receptor 9|Interferon-inducible protein 10 receptor (IP-10 receptor) |CXCR3|GPR9
Gene ID
2833
UniProt
P49682
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
CXCR3
Target
CXCR3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Stem Cells, Immunology, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
45 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · P49682

C-X-C chemokine receptor type 3

CXCR3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P49682
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CXCR3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CXC-R3, CXCR-3
EC number
—
Processing
—
Secondary accessions
B2R982, O15185, Q7Z710, Q9P2T4, Q9P2T5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

AngiogenesisApoptosisChemotaxis

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinSulfation

Molecular function

G protein-coupled receptorReceptorTransducer

Domain

TransmembraneTransmembrane helix

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