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CXCR4 antibody

CAT: 0710-FNab02103Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02103Size:100 µg
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Background
The chemokine receptor CXCR4, a 7-transmembrane protein on cell surface, acts with the CD4 protein to support HIV entry into cells. CXCR4 is highly expressed in brain and heart, white blood cells, vascular endothelial cells, and umbilical cord endothelial cells. Several CXCR4 isoforms have been identified with molecular weights of 47, 50, 62 and 98kDa. The 62-64kDa CXCR4 is predominantly ubiquitinated and is preferentially associated with CD4. This antibody recognizes the 62kd CXCR4.
Synonyms
C-X-C chemokine receptor type 4 (CXC-R4, CXCR-4) |FB22|Fusin|HM89|LCR1|Leukocyte-derived seven transmembrane domain receptor (LESTR) |Lipopolysaccharide-associated protein 3 (LAP-3, LPS-associated protein 3) |NPYRL|Stromal cell-derived factor 1 receptor (SDF-1 receptor) |CXCR4
Gene ID
7852
UniProt
P61073
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Chemokine (C-X-C motif) receptor 4
Target
CXCR4
Clonality
Monoclonal
Isotype
IgG2a
Applications
ELISA, WB, FC
Field of Research
Signal Transduction, Immunology, Developmental biology, Neuroscience, Stem Cells
Purification
Protein A+G purification
Dilution
WB: 1:500-1:5000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
60-70 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
9H1
Tested Applications
ELISA, WB, FC
Immunogen Sequence
200-352aa

UniProtKB · P61073

C-X-C chemokine receptor type 4

CXCR4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P61073
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CXCR4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CXC-R4, CXCR-4
EC number
—
Processing
—
Secondary accessions
B2R5N0, O60835, P30991, P56438, Q53S69, Q9BXA0, Q9UKN2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell junctionCell membraneEndosomeLysosomeMembrane

Disease

Disease variant

PTM

Disulfide bondGlycoproteinIsopeptide bondPhosphoproteinProteoglycanSulfationUbl conjugation

Molecular function

G protein-coupled receptorHost cell receptor for virus entryReceptorTransducer

Biological process

Host-virus interaction

Domain

TransmembraneTransmembrane helix

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