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CXCR4 antibody

CAT: 0710-FNab02102Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02102Size:100 µg
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Background
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Synonyms
C-X-C chemokine receptor type 4 (CXC-R4, CXCR-4) |FB22|Fusin|HM89|LCR1|Leukocyte-derived seven transmembrane domain receptor (LESTR) |Lipopolysaccharide-associated protein 3 (LAP-3, LPS-associated protein 3) |NPYRL|Stromal cell-derived factor 1 receptor (SDF-1 receptor) |CXCR4
Gene ID
7852
UniProt
P61073
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Chemokine (C-X-C motif) receptor 4
Target
CXCR4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB
Field of Research
Signal Transduction, Immunology, Developmental biology, Neuroscience, Stem Cells
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
60 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB
Immunogen Sequence
1-50aa

UniProtKB · P61073

C-X-C chemokine receptor type 4

CXCR4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P61073
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CXCR4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CXC-R4, CXCR-4
EC number
—
Processing
—
Secondary accessions
B2R5N0, O60835, P30991, P56438, Q53S69, Q9BXA0, Q9UKN2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell junctionCell membraneEndosomeLysosomeMembrane

Disease

Disease variant

PTM

Disulfide bondGlycoproteinIsopeptide bondPhosphoproteinProteoglycanSulfationUbl conjugation

Molecular function

G protein-coupled receptorHost cell receptor for virus entryReceptorTransducer

Biological process

Host-virus interaction

Domain

TransmembraneTransmembrane helix

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