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CXCR4 antibody

CAT: 0710-FNab10437Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab10437Size:100 µg
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Background
C-X-C chemokine receptor type 4 (CXCR4) is a widely expressed G protein-coupled seven-transmembrane receptor. CXCL12/SDF-1 is the biological ligand for CXCR4. The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription (PMID: 20484021) . CXCR4 also functions as a coreceptor for HIV-1 entry (PMID: 9427609) . CXCR4 has a calculated molecular weight of 40 kDa. In addition to the predicted species of 45-47 kDa for glycosylated CXCR4 monomers, due to ubiquitination, dimeration, and different degrees of glycosylation, additional species can also exist and have been reported in some researches, including 67 kDa (PMID: 23917520), 55, 67, 87 kDa (PMID: 20028517), 80 kDa (PMID: 10506573), 47, 50, 62, and 98 kDa (PMID: 16204649) .
Synonyms
C-X-C chemokine receptor type 4 (CXC-R4, CXCR-4) |FB22|Fusin|HM89|LCR1|Leukocyte-derived seven transmembrane domain receptor (LESTR) |Lipopolysaccharide-associated protein 3 (LAP-3, LPS-associated protein 3) |NPYRL|Stromal cell-derived factor 1 receptor (SDF-1 receptor) |CXCR4
Gene ID
7852
UniProt
P61073
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Chemokine (C-X-C motif) receptor 4
Target
CXCR4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction, Immunology, Developmental biology, Neuroscience, Stem Cells
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
40 kDa, 55 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
1-50aa

UniProtKB · P61073

C-X-C chemokine receptor type 4

CXCR4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P61073
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CXCR4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CXC-R4, CXCR-4
EC number
—
Processing
—
Secondary accessions
B2R5N0, O60835, P30991, P56438, Q53S69, Q9BXA0, Q9UKN2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell junctionCell membraneEndosomeLysosomeMembrane

Disease

Disease variant

PTM

Disulfide bondGlycoproteinIsopeptide bondPhosphoproteinProteoglycanSulfationUbl conjugation

Molecular function

G protein-coupled receptorHost cell receptor for virus entryReceptorTransducer

Biological process

Host-virus interaction

Domain

TransmembraneTransmembrane helix

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