MAP3K20 antibody

• Background:

  This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

• Synonyms:

  Mitogen-activated protein kinase kinase kinase 20|Human cervical cancer suppressor gene 4 protein (HCCS-4)|Leucine zipper- and sterile alpha motif-containing kinase|MLK-like mitogen-activated protein triple kinase|Mitogen-activated protein kinase kinase kinase MLT|Mixed lineage kinase 7|Mixed lineage kinase-related kinase (MLK-related kinase, MRK)|Sterile alpha motif- and leucine zipper-containing kinase AZK|MAP3K20|MLK7|MLTK|ZAK

• Gene ID:

  51776

• UniProt:

  Q9NYL2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  sterile alpha motif and leucine zipper containing kinase AZK

• Target:

  MAP3K20

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC, IF

• Field of Research:

  Signal Transduction, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20 - 1:50

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  55 kDa, 100 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• CAS Number:

  9007-83-4