MAPK10 antibody

CAT: 0710-FNab04987Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab04987Size:100 µg
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Background
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692) .
Synonyms
Mitogen-activated protein kinase 10 (MAP kinase 10, MAPK 10) |MAP kinase p49 3F12|Stress-activated protein kinase 1b (SAPK1b) |Stress-activated protein kinase JNK3|c-Jun N-terminal kinase 3|MAPK10|JNK3|JNK3A|PRKM10|SAPK1B
Gene ID
5602
UniProt
P53779
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Mitogen-activated protein kinase 10
Target
MAPK10
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF
Field of Research
Immunology, Cardiovascular, Metabolism, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
45-48 kDa, 54-57 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF

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