MAP4K2 antibody

• Background :

  Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extend of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly (IC) ), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion.

• Synonyms :

  Mitogen-activated protein kinase kinase kinase kinase 2|B lymphocyte serine/threonine-protein kinase|Germinal center kinase (GC kinase) |MAPK/ERK kinase kinase kinase 2 (MEK kinase kinase 2, MEKKK 2) |Rab8-interacting protein|MAP4K2|GCK|RAB8IP

• Gene ID :

  5871

• UniProt :

  Q12851

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Mitogen-activated protein kinase kinase kinase kinase 2

• Target :

  MAP4K2

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB

• Field of Research :

  Metabolism

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:2000

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  85-91 kDa, 58 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB