ERCC5 antibody

• Background:

  The human genes correcting DNA repair defects are termed excision-repair cross-complementing or ERCC genes. The ERCC5 gene corrects the excision repair deficiency of Chinese hamster ovary cell line UV135 of complementation group 5. The human ERCC5 gene product is a structure-specific endonuclease required for making the 3-prime incision during DNA nucleotide excision-repair (NER) . It also plays an important role in regulating DNA excision repair, removal of bulky lesions caused by environmental chemicals or UV light [PMID:22815677].

• Synonyms:

  DNA excision repair protein ERCC-5|DNA repair protein complementing XP-G cells|Xeroderma pigmentosum group G-complementing protein|ERCC5|ERCM2|XPG|XPGC

• UniProt:

  P28715

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Excision repair cross-complementing rodent repair deficiency, complementation group 5

• Target:

  ERCC5

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IP

• Field of Research:

  Epigenetics, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:200-1:2000; IF: 1:20-1:200; IP: 1:200-1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  200 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IP