ERCC2 antibody

• Background:

  ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.

• Synonyms:

  General transcription and DNA repair factor IIH helicase subunit XPD (TFIIH subunit XPD) |Basic transcription factor 2 80 kDa subunit (BTF2 p80) |CXPD|DNA excision repair protein ERCC-2|DNA repair protein complementing XP-D cells|TFIIH basal transcription factor complex 80 kDa subunit (TFIIH 80 kDa subunit, TFIIH p80) |Xeroderma pigmentosum group D-complementing protein|ERCC2|XPD|XPDC

• Gene ID:

  2068

• UniProt:

  P18074

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Excision repair cross-complementing rodent repair deficiency, complementation group 2

• Target:

  ERCC2

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB

• Field of Research:

  Epigenetics, Cancer, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  80 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB