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ERCC6 antibody

CAT: 0710-FNab02836Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab02836Size:100 µg
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Background
Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX (ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions.
Synonyms
DNA excision repair protein ERCC-6|ATP-dependent helicase ERCC6|Cockayne syndrome protein CSB|ERCC6|CSB
Gene ID
2074
UniProt
Q03468
Host
Rabbit
Reactivity
Human
Immunogen
Excision repair cross-complementing rodent repair deficiency, complementation group 6
Target
ERCC6
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
150 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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