ERCC2 antibody

• Background :

  ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.

• Synonyms :

  General transcription and DNA repair factor IIH helicase subunit XPD (TFIIH subunit XPD) |Basic transcription factor 2 80 kDa subunit (BTF2 p80) |CXPD|DNA excision repair protein ERCC-2|DNA repair protein complementing XP-D cells|TFIIH basal transcription factor complex 80 kDa subunit (TFIIH 80 kDa subunit, TFIIH p80) |Xeroderma pigmentosum group D-complementing protein|ERCC2|XPD|XPDC

• Gene ID :

  2068

• UniProt :

  P18074

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  Excision repair cross-complementing rodent repair deficiency, complementation group 2

• Target :

  ERCC2

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IHC, IP

• Field of Research :

  Epigenetics, Cancer, Metabolism

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  80 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IHC, IP