USP1 antibody

• Background:

  Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335) . Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995) . Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029) .

• Synonyms:

  Ubiquitin carboxyl-terminal hydrolase 1|Deubiquitinating enzyme 1 (hUBP) |Ubiquitin thioesterase 1|Ubiquitin-specific-processing protease 1|Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment|USP1

• Gene ID:

  7398

• UniProt:

  O94782

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Ubiquitin specific peptidase 1

• Target:

  USP1

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Epigenetics, Metabolism

• Purification:

  Protein A+G purification

• Dilution:

  WB: 1:1000-1:10000; IHC: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  90 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID:

  8F7

• Tested Applications:

  ELISA, WB, IHC

• Immunogen Sequence:

  430-785aa