USP1 antibody

• Background :

  Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335) . Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995) . Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029) .

• Synonyms :

  Ubiquitin carboxyl-terminal hydrolase 1|Deubiquitinating enzyme 1 (hUBP) |Ubiquitin thioesterase 1|Ubiquitin-specific-processing protease 1|Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment|USP1

• Gene ID :

  7398

• UniProt :

  O94782

• Host :

  Mouse

• Reactivity :

  Human

• Immunogen :

  Ubiquitin specific peptidase 1

• Target :

  USP1

• Clonality :

  Monoclonal

• Isotype :

  IgG1

• Applications :

  ELISA, WB, IHC

• Field of Research :

  Epigenetics, Metabolism

• Purification :

  Protein A+G purification

• Dilution :

  WB: 1:1000-1:10000; IHC: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  90 kDa

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID :

  8F7

• Tested Applications :

  ELISA, WB, IHC

• Immunogen Sequence :

  430-785aa