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USP16 antibody

CAT: 0710-FNab09312Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09312Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B-and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Synonyms
Ubiquitin carboxyl-terminal hydrolase 16|Deubiquitinating enzyme 16|Ubiquitin thioesterase 16|Ubiquitin-processing protease UBP-M|Ubiquitin-specific-processing protease 16|USP16
Gene ID
10600
UniProt
Q9Y5T5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Ubiquitin specific peptidase 16
Target
USP16
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
94 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP

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