SETDB2 antibody

• Background:

  Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) . H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.

• Synonyms:

  Histone-lysine N-methyltransferase SETDB2|Chronic lymphocytic leukemia deletion region gene 8 protein|Lysine N-methyltransferase 1F|SET domain bifurcated 2|SETDB2|C13orf4|CLLD8|KMT1F

• Gene ID:

  83852

• UniProt:

  Q96T68

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  SET domain, bifurcated 2

• Target:

  SETDB2

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB

• Field of Research:

  Epigenetics, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  101 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB