SETD7 antibody

• Background:

  Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

• Synonyms:

  Histone-lysine N-methyltransferase SETD7|Histone H3-K4 methyltransferase SETD7 (H3-K4-HMTase SETD7) |Lysine N-methyltransferase 7|SET domain-containing protein 7|SET7/9|SETD7|KIAA1717|KMT7|SET7|SET9

• Gene ID:

  80854

• UniProt:

  Q8WTS6

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  SET domain containing (lysine methyltransferase) 7

• Target:

  SETD7

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB

• Field of Research:

  Epigenetics, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  48-50 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB