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SETD7 antibody

CAT: 0710-FNab07769Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab07769Size:100 µg
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Background
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Synonyms
Histone-lysine N-methyltransferase SETD7|Histone H3-K4 methyltransferase SETD7 (H3-K4-HMTase SETD7) |Lysine N-methyltransferase 7|SET domain-containing protein 7|SET7/9|SETD7|KIAA1717|KMT7|SET7|SET9
Gene ID
80854
UniProt
Q8WTS6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
SET domain containing (lysine methyltransferase) 7
Target
SETD7
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
48-50 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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