SETD1B antibody

• Background :

  Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.

• Synonyms :

  Histone-lysine N-methyltransferase SETD1B|Lysine N-methyltransferase 2G|SET domain-containing protein 1B (hSET1B) |SETD1B|KIAA1076|KMT2G|SET1B

• Gene ID :

  23067

• UniProt :

  Q9UPS6

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  SET domain containing 1B

• Target :

  SETD1B

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IP, IHC,IF

• Field of Research :

  Epigenetics, Metabolism

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:50-1:500

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  260 kDa

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IP, IHC, IF

• Immunogen Sequence :

  Peptide (350-459aa)