SETD1B antibody

• Background:

  Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.

• Synonyms:

  Histone-lysine N-methyltransferase SETD1B|Lysine N-methyltransferase 2G|SET domain-containing protein 1B (hSET1B) |SETD1B|KIAA1076|KMT2G|SET1B

• Gene ID:

  23067

• UniProt:

  Q9UPS6

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  SET domain containing 1B

• Target:

  SETD1B

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IP, IHC,IF

• Field of Research:

  Epigenetics, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:50-1:500

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  260 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IP, IHC, IF

• Immunogen Sequence:

  Peptide (350-459aa)