RNF4 antibody

• Background:

  E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'-and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

• Synonyms:

  E3 ubiquitin-protein ligase RNF4|RING finger protein 4|Small nuclear ring finger protein (Protein SNURF) |RNF4|SNURF

• Gene ID:

  6047

• UniProt:

  P78317

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Ring finger protein 4

• Target:

  RNF4

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, IP

• Field of Research:

  Cancer, Metabolism, Developmental biology

• Purification:

  Immunogen affinity purified

• Dilution:

  IP: 1:200-1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, IP