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RNF34 antibody

CAT: 710-FNab10144Size: 100 µgDry Ice: NoHazardous: No
100 µgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192) . May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13) . Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812) . Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127) . Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484) . Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219) .
Synonyms
E3 ubiquitin-protein ligase RNF34|Caspase regulator CARP1|Caspases-8 and -10-associated RING finger protein 1 (CARP-1) |FYVE-RING finger protein Momo|Human RING finger homologous to inhibitor of apoptosis protein (hRFI) |RING finger protein 34|RING finger protein RIFF|RING-type E3 ubiquitin transferase RNF34|RNF34
Gene ID
80196
UniProt
Q969K3
Host
Rabbit
Reactivity
Human
Immunogen
Ring finger protein 34
Target
RNF34
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Field of Research
Cell Division and Proliferation
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
41 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
WB

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