RNF41 antibody

CAT: 0710-FNab07359Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab07359Size:100 µg
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Background
Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity) . Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity) . Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970) .
Synonyms
E3 ubiquitin-protein ligase NRDP1|RING finger protein 41|RING-type E3 ubiquitin transferase NRDP1|RNF41|FLRF|NRDP1
Gene ID
10193
UniProt
Q9H4P4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Ring finger protein 41
Target
RNF41
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
36 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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