RNF6 antibody

• Background :

  E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.

• Synonyms :

  E3 ubiquitin-protein ligase RNF6|RNF6|SPG2

• Gene ID :

  6049

• UniProt :

  Q9Y252

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  Ring finger protein (C3H2C3 type) 6

• Target :

  RNF6

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IF

• Field of Research :

  Epigenetics, Developmental biology

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:2000; IF: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  78 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IF