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POLR3G antibody

CAT: 0710-FNab06633Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06633Size:100 µg
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Background
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway.
Synonyms
DNA-directed RNA polymerase III subunit RPC7 (RNA polymerase III subunit C7) |DNA-directed RNA polymerase III subunit G|RNA polymerase III 32 kDa apha subunit (RPC32-alpha) |RNA polymerase III 32 kDa subunit (RPC32) |POLR3G
Gene ID
10622
UniProt
O15318
Host
Rabbit
Reactivity
Human
Immunogen
Polymerase (RNA) III (DNA directed) polypeptide G (32kD)
Target
POLR3G
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Immunology, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
26-30 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

UniProtKB · O15318

DNA-directed RNA polymerase III subunit RPC7

RPC7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15318
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
POLR3G
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
RNA polymerase III subunit C7
EC number
—
Processing
—
Secondary accessions
A8MTH0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Antiviral defenseImmunityInnate immunityTranscription

Cellular component

CytoplasmDNA-directed RNA polymeraseNucleus

PTM

Phosphoprotein

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