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POLR1A antibody

CAT: 0710-FNab06615Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06615Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity) .
Synonyms
DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) |A190|DNA-directed RNA polymerase I largest subunit|DNA-directed RNA polymerase I subunit A|RNA polymerase I 194 kDa subunit (RPA194) |POLR1A
Gene ID
25885
UniProt
O95602
Host
Rabbit
Reactivity
Human
Immunogen
Polymerase (RNA) I polypeptide A, 194kDa
Target
POLR1A
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
190-195 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
Immunogen Sequence
1440-1720aa

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