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POLR3K antibody

CAT: 0710-FNab06634Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06634Size:100 µg
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Background
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway (By similarity) .
Synonyms
DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10) |DNA-directed RNA polymerase III subunit K|RNA polymerase III 12.5 kDa subunit (RPC12.5) |RNA polymerase III subunit C11 (HsC11p, RPC11, hRPC11) |POLR3K|RPC11
Gene ID
51728
UniProt
Q9Y2Y1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
Target
POLR3K
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, IF, WB
Field of Research
Immunology, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
12 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, IF, WB

UniProtKB · Q9Y2Y1

DNA-directed RNA polymerase III subunit RPC10

RPC10_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y2Y1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
POLR3K
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
RNA polymerase III subunit C10
EC number
—
Processing
—
Secondary accessions
Q1W6H4, Q96S35
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Antiviral defenseImmunityInnate immunityTranscription

Disease

Disease variantLeukodystrophyNeurodegeneration

Cellular component

DNA-directed RNA polymeraseNucleus

Ligand

Metal-bindingZinc

Domain

Zinc-finger

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