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MED12L antibody

CAT: 0710-FNab05088Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05088Size:100 µg
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Background
May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity) .
Synonyms
Mediator of RNA polymerase II transcription subunit 12-like protein|Mediator complex subunit 12-like protein|Thyroid hormone receptor-associated-like protein|Trinucleotide repeat-containing gene 11 protein-like|MED12L|KIAA1635|TNRC11L|TRALP|TRALPUSH
Gene ID
116931
UniProt
Q86YW9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Mediator complex subunit 12-like
Target
MED12L
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
260-280 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

UniProtKB · Q86YW9

Mediator of RNA polymerase II transcription subunit 12-like protein

MD12L_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q86YW9
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MED12L
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q96PC7, Q96PC8, Q9H9M5, Q9HCD7, Q9UI69
Protein keywords

Molecular function

ActivatorRepressor

Coding sequence diversity

Alternative splicing

Disease

Autism spectrum disorderDisease variantIntellectual disability

Cellular component

Nucleus

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Biological process

TranscriptionTranscription regulation

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