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MED12 antibody

CAT: 0710-FNab05087Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05087Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
Synonyms
Mediator of RNA polymerase II transcription subunit 12|Activator-recruited cofactor 240 kDa component (ARC240) |CAG repeat protein 45|Mediator complex subunit 12|OPA-containing protein|Thyroid hormone receptor-associated protein complex 230 kDa component (Trap230) |Trinucleotide repeat-containing gene 11 protein|MED12|ARC240|CAGH45|HOPA|KIAA0192|TNRC11|TRAP230
Gene ID
9968
UniProt
Q93074
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Mediator complex subunit 12
Target
MED12
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
230 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

UniProtKB · Q93074

Mediator of RNA polymerase II transcription subunit 12

MED12_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q93074
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MED12
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
O15410, O75557, Q9UHV6, Q9UND7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationMethylationPhosphoprotein

Molecular function

ActivatorRepressor

Coding sequence diversity

Alternative splicing

Disease

Disease variantIntellectual disability

Cellular component

Nucleus

Biological process

TranscriptionTranscription regulation

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