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MED15 antibody

CAT: 0710-FNab05089Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05089Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.
Synonyms
Mediator of RNA polymerase II transcription subunit 15|Activator-recruited cofactor 105 kDa component (ARC105) |CTG repeat protein 7a|Mediator complex subunit 15|Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) |TPA-inducible gene 1 protein (TIG-1) |Trinucleotide repeat-containing gene 7 protein|MED15|ARC105|CTG7A|PCQAP|TIG1|TNRC7
Gene ID
51586
UniProt
Q96RN5
Host
Rabbit
Reactivity
Human
Immunogen
Mediator complex subunit 15
Target
MED15
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
105 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP

UniProtKB · Q96RN5

Mediator of RNA polymerase II transcription subunit 15

MED15_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96RN5
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MED15
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
D3DX31, D3DX32, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

Activator

Coding sequence diversity

Alternative splicingTriplet repeat expansion

Cellular component

CytoplasmNucleus

PTM

MethylationPhosphoproteinUbl conjugation

Biological process

TranscriptionTranscription regulation

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