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IFIT1 antibody

CAT: 0710-FNab04135Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab04135Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism) . Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.
Synonyms
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) |Interferon-induced 56 kDa protein (IFI-56K, P56) |IFIT1|G10P1|IFI56|IFNAI1|ISG56
Gene ID
3434
UniProt
P09914
Host
Rabbit
Reactivity
Human, Rat, Mouse
Immunogen
Interferon-induced protein with tetratricopeptide repeats 1
Target
IFIT1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB
Field of Research
Immunology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
55 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB

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