IFIH1 antibody

Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length) . Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs) ; IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG) . Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L) . May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.

Interferon-induced helicase C domain-containing protein 1|Clinically amyopathic dermatomyositis autoantigen 140 kDa (CADM-140 autoantigen) |Helicase with 2 CARD domains (Helicard) |Interferon-induced with helicase C domain protein 1|Melanoma differentiation-associated protein 5 (MDA-5) |Murabutide down-regulated protein|RIG-I-like receptor 2 (RLR-2) |RNA helicase-DEAD box protein 116|IFIH1|MDA5|RH116

64135

Q9BYX4

Human

Interferon induced with helicase C domain 1

IFIH1

ELISA, WB, IP

Immunology, Metabolism

Immunogen affinity purified

WB: 1:500-1:2000; IP: 1:200-1:2000

≥95% as determined by SDS-PAGE

Liquid

117-125 kDa

4°C with ice bag

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

ELISA, WB, IP