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IFIT2 antibody

CAT: 0710-FNab04137Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab04137Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism) . Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
Synonyms
Interferon-induced protein with tetratricopeptide repeats 2 (IFIT-2) |ISG-54 K|Interferon-induced 54 kDa protein (IFI-54K, P54) |IFIT2|CIG-42|G10P2|IFI54|ISG54
Gene ID
3433
UniProt
P09913
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Interferon-induced protein with tetratricopeptide repeats 2
Target
IFIT2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Immunology
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50-55 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

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