IFIT2 antibody

• Background:

  IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism) . Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.

• Synonyms:

  Interferon-induced protein with tetratricopeptide repeats 2 (IFIT-2) |ISG-54 K|Interferon-induced 54 kDa protein (IFI-54K, P54) |IFIT2|CIG-42|G10P2|IFI54|ISG54

• Gene ID:

  3433

• UniProt:

  P09913

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Interferon-induced protein with tetratricopeptide repeats 2

• Target:

  IFIT2

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC, IF

• Field of Research:

  Immunology

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:200-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  50-55 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC, IF