EIF3M antibody

• Background:

  Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC) . The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2) .

• Synonyms:

  Eukaryotic translation initiation factor 3 subunit M (eIF3m) |Fetal lung protein B5 (hFL-B5) |PCI domain-containing protein 1|EIF3M|HFLB5|PCID1

• Gene ID:

  10480

• UniProt:

  Q7L2H7

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Eukaryotic translation initiation factor 3, subunit M

• Target:

  EIF3M

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Applications:

  ELISA, WB, IF

• Field of Research:

  Metabolism

• Purification:

  Protein A+G purification

• Dilution:

  WB: 1:500-1:2000; IF: 1:10-1:100

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  43 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID:

  1A4

• Tested Applications:

  ELISA, WB, IF

• Immunogen Sequence:

  1-374aa