CASP12 antibody

• Background:

  Caspase 12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. It is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. Caspase-12 is located in the endoplasmic reticulum (ER). It is responsible for ER-stress-induced apoptosis, such as high calcium concentration, low oxygen and low glucose levels. This antibody detects endogenous levels of full-length caspase-12 protein (50 kDa) and its cleaved product (40-44 kDa).

• Synonyms:

  Inactive caspase-12 (CASP-12)|CASP12

• UniProt:

  Q6UXS9

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  caspase 12(gene/pseudogene)

• Target:

  CASP12

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, IF, IHC, WB, IP

• Field of Research:

  Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  36-42 kDa, 50 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

• CAS Number:

  9007-83-4