CASP1 antibody

• Background:

  CASP1 (caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products (PMID:21804020) . It has 5 isoforms produced by alternative splicing.

• Synonyms:

  Caspase-1 (CASP-1) |Interleukin-1 beta convertase (IL-1BC) |Interleukin-1 beta-converting enzyme (ICE, IL-1 beta-converting enzyme) |p45|Caspase-1 subunit p20|Caspase-1 subunit p10|CASP1|IL1BC|IL1BCE

• Gene ID:

  834

• UniProt:

  P29466

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)

• Target:

  CASP1

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000; IHC: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  45-47 kDa, 30 kDa, 35 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC

• Immunogen Sequence:

  Peptide (p20)