CASP1 antibody
CAT:
710-FNab01284
Size:
100 µg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
CASP1 antibody
- Background: CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta(IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products(PMID:21804020). It has 5 isoforms produced by alternative splicing.
- Synonyms: Caspase-1 (CASP-1)|Interleukin-1 beta convertase (IL-1BC)|Interleukin-1 beta-converting enzyme (ICE, IL-1 beta-converting enzyme)|p45|Caspase-1 subunit p20|Caspase-1 subunit p10|CASP1|IL1BC|IL1BCE
- CAS Number: 9007-83-4
- Gene ID: 834
- UniProt: P29466
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Immunogen: caspase 1, apoptosis-related cysteine peptidase(interleukin 1, beta, convertase)
- Target: CASP1
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, WB, IHC
- Field of Research: Metabolism
- Purification: Immunogen affinity purified
- Dilution: WB: 1:500-1:2000;IHC: 1:20-1:200
- Purity: ≥95% as determined by SDS-PAGE
- Form: Liquid
- Molecular Weight: 45-47 kDa, 30 kDa, 35 kDa
- Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)