CASP2 antibody

• Background:

  This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

• Synonyms:

  Caspase-2 (CASP-2) |Neural precursor cell expressed developmentally down-regulated protein 2 (NEDD-2) |Protease ICH-1|Caspase-2 subunit p18|Caspase-2 subunit p13|Caspase-2 subunit p12|CASP2|ICH1|NEDD2

• UniProt:

  P42575

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Caspase 2, apoptosis-related cysteine peptidase

• Target:

  CASP2

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000; IHC: 1:50-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  50 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC