BPU-11

• Description :

  BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand. BPU-11 can be used for the research of congenital immune disease[1].

• Product Name Alternative :

  AHPN, AHPN-13C6

• UNSPSC :

  12352005

• Target :

  HCN Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/bpu-11.html

• Concentration :

  10mM

• Purity :

  98.08

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C(N(CC1=CC=CN=C1)C2CCN(CC2)CC3=CC=CC(C#N)=C3)NC4=CC=CC=C4C5=CC=CC=C5

• Molecular Formula :

  C32H31N5O

• Molecular Weight :

  501.62

• References & Citations :

  [1]Lolicato M, et al. Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness. Nat Chem Biol. 2014 Jun;10 (6) :457-62.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [909664-41-1]