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BAY-1797

CAT: 0804-HY-130605-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-130605-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAY-1797, a chemical probe, is a potent, orally active, and selective P2X4 antagonist, with an IC50 of 211 nM against human P2X4. BAY-1797 displays no or very weak activity on the other P2X ion channels. BAY-1797 shows anti-nociceptive and anti-inflammatory effects[1].
CAS Number
2055602-83-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bay-1797.html
Purity
99.76
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(OC2=CC=CC(Cl)=C2)C(S(=O)(N)=O)=C1)CC3=CC=CC=C3
Molecular Formula
C20H17ClN2O4S
Molecular Weight
416.88
Precautions
H302, H315, H319, H335
References & Citations
[1]Werner S, et al. Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4- (3-Chlorophenoxy) -3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile. J Med Chem. 2019 Dec 26;62 (24) :11194-11217.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2X4 Receptor

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