Methyldopa (hydrochloride)

• Description:

  Methyldopa hydrochloride (L- (-) -α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) . Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system[1][2].

• Product Name Alternative:

  L- (-) -α-Methyldopa (hydrochloride) ; MK-351 (hydrochloride)

• UNSPSC:

  12352005

• Target:

  Adrenergic Receptor; Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cardiovascular Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/l-_-_-_alpha_-methyldopa-hydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=C(O)C=CC(C[C@@](C)(C(O)=O)N)=C1.Cl

• Molecular Formula:

  C10H14ClNO4

• Molecular Weight:

  247.68

• References & Citations:

  [1]Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6 (5 Pt 2) :II51-II56.|[2]Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78 (3) :342-350.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  α adrenergic receptor

• CAS Number:

  [884-39-9]