Methyldopa

• Description :

  Methyldopa (L- (-) -α-Methyldopa), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) . Methyldopa is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system[1][2].

• Product Name Alternative :

  L- (-) -α-Methyldopa; MK-351

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Adrenergic Receptor; Endogenous Metabolite

• Type :

  Natural Products

• Related Pathways :

  GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cardiovascular Disease; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/l-_-_-_alpha_-methyldopa.html

• Concentration :

  10mM

• Purity :

  98.25

• Solubility :

  DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  OC1=C(O)C=CC(C[C@@](C)(C(O)=O)N)=C1

• Molecular Formula :

  C10H13NO4

• Molecular Weight :

  211.22

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6 (5 Pt 2) :II51-II56.|[2]Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78 (3) :342-350.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• Isoform :

  α adrenergic receptor

• Citation 01 :

  Clin Chem. 2019 Dec;65 (12) :1522-1531. |Cell Rep Methods. 2023 Oct 23;3 (10) :100599.

• CAS Number :

  [555-30-6]