Methyldopa

• Description:

  Methyldopa (L- (-) -α-Methyldopa), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) . Methyldopa is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system[1][2].

• Product Name Alternative:

  L- (-) -α-Methyldopa; MK-351

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Adrenergic Receptor; Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cardiovascular Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/l-_-_-_alpha_-methyldopa.html

• Concentration:

  10mM

• Purity:

  98.25

• Solubility:

  DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  OC1=C(O)C=CC(C[C@@](C)(C(O)=O)N)=C1

• Molecular Formula:

  C10H13NO4

• Molecular Weight:

  211.22

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6 (5 Pt 2) :II51-II56.|[2]Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78 (3) :342-350.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  α adrenergic receptor

• Citation 01:

  Clin Chem. 2019 Dec;65 (12) :1522-1531. |Cell Rep Methods. 2023 Oct 23;3 (10) :100599.

• CAS Number:

  [555-30-6]