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Methyldopa (hydrate)

CAT: 0804-HY-B0225B-01Size: 5 gDry Ice: NoHazardous: No
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CAT#:0804-HY-B0225B-01Size:5 g
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Description
Methyldopa hydrate (L- (-) -α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) . Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system[1][2].
CAS Number
41372-08-1
Product Name Alternative
L- (-) -α-Methyldopa (hydrate) ; MK-351 (hydrate)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adrenergic Receptor; Endogenous Metabolite
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/L-_-_-_alpha_-Methyldopa-hydrate.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : 25 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic)
Smiles
OC1=C(O)C=CC(C[C@@](C)(C(O)=O)N)=C1.O
Molecular Formula
C10H16NO5.5
Molecular Weight
238.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6 (5 Pt 2) :II51-II56.|[2]Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78 (3) :342-350.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
α adrenergic receptor
Citation 01
Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Clin Chem. 2019 Dec;65 (12) :1522-1531.

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