Methyldopa (hydrate)

• UNSPSC Description:

  Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system[1][2].

• Target Antigen:

  Adrenergic Receptor; Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/L-_-_-_alpha_-Methyldopa-hydrate.html

• Purity:

  99.95

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)|H2O : 1 mg/mL (ultrasonic)

• Smiles:

  OC1=C(O)C=CC(C[C@@](C)(C(O)=O)N)=C1.O

• Molecular Weight:

  238.24

• References & Citations:

  [1]Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6(5 Pt 2):II51-II56.|[2]Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78(3):342-350.Cell Rep Methods. 2023 Oct 23;3(10):100599.|Clin Chem. 2019 Dec;65(12):1522-1531.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  41372-08-1