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Methyldopa-d3 (hydrochloride)

CAT: 0804-HY-B0225AS-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0225AS-01Size:1 mg
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Description
Methyldopa-d3 (hydrochloride) is deuterium labeled Methyldopa (hydrochloride) . Methyldopa hydrochloride (L- (-) -α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) . Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system[1][2].
Product Name Alternative
L- (-) -α-Methyldopa-d3 (hydrochloride) ; MK-351-d3 (hydrochloride)
UNSPSC
12352005
Target
Adrenergic Receptor; Endogenous Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])[C@@](CC1=CC=C(O)C(O)=C1)(N)C(O)=O.[H]Cl
Molecular Formula
C10H11D3ClNO4
Molecular Weight
250.69
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78 (3) :342-350.|[3]Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6 (5 Pt 2) :II51-II56.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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