Tigecycline (mesylate)

Tigecycline (mesylate)

• CAS Number: 1135871-27-0
• UNSPSC Description: Tigecycline mesylate (GAR-936 mesylate) is a broad-spectrum glycylcycline antibiotic. The mean inhibitory concentration (MIC) of Tigecycline for E. coli (MG1655 strain) is approximately 125 ng/mL[1]. MIC50 and MIC90 are 1 and 2 mg/L for Acinetobacter baumannii (A. baumannii), respectively[2].
• Target Antigen: Antibiotic; Autophagy; Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection;Autophagy
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/tigecycline-mesylate.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@]3([H])CC4=C(C(C3=C(O)[C@@]21O)=O)C(O)=C(NC(CNC(C)(C)C)=O)C=C4N(C)C)N.O=S(C)(O)=O
• Molecular Weight: 681.75
• References & Citations: [1]Jitkova Y, et al. A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity. PLoS One. 2014 May 28;9(5):e95281.|[2]Falagas ME, et al. Activity of TP-6076 against carbapenem-resistant Acinetobacter baumannii isolates collected from inpatients in Greek hospitals. Int J Antimicrob Agents. 2018 Aug;52(2):269-271.
• Shipping Conditions: Room temperature
• Clinical Information: Launched