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Tigecycline-d9

CAT: 0804-HY-B0117SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0117SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tigecycline-d9 is deuterium labeled Tigecycline. Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic. The mean inhibitory concentration (MIC) of Tigecycline for E. coli (MG1655 strain) is approximately 125 ng/mL[1]. MIC50 and MIC90 are 1 and 2 mg/L for Acinetobacter baumannii (A. baumannii), respectively[2].
CAS Number
2699607-86-6
Product Name Alternative
GAR-936-d9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Autophagy; Bacterial
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Purity
98.2
Solubility
10 mM in DMSO
Smiles
O[C@]12[C@](C[C@@]3([H])C(C(C4=C(O)C(NC(CNC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=CC(N(C)C)=C4C3)=O)=C2O)([H])[C@@H](C(O)=C(C1=O)C(N)=O)N(C)C
Molecular Formula
C29H30D9N5O8
Molecular Weight
594.70
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Falagas ME, et al. Activity of TP-6076 against carbapenem-resistant Acinetobacter baumannii isolates collected from inpatients in Greek hospitals. Int J Antimicrob Agents. 2018 Aug;52 (2) :269-271.|[3]Jitkova Y, et al. A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity. PLoS One. 2014 May 28;9 (5) :e95281.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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