Tigecycline (hydrochloride)

CAT: 0804-HY-B0117A-01Size: 5 mgDry Ice: NoHazardous: No

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Description

Tigecycline hydrochloride (GAR-936 hydrochloride) is a broad-spectrum glycylcycline antibiotic. The mean inhibitory concentration (MIC) of Tigecycline for E. coli (MG1655 strain) is approximately 125 ng/mL[1]. MIC50 and MIC90 are 1 and 2 mg/L for Acinetobacter baumannii (A. baumannii), respectively[2].

CAS Number

197654-04-9

Product Name Alternative

GAR-936 hydrochloride

UNSPSC

12352005

Target

Antibiotic; Autophagy; Bacterial

Type

Reference compound

Related Pathways

Anti-infection; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Tigecycline-hydrochloride.html

Purity

99.56

Solubility

10 mM in DMSO

Smiles

O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@]3([H])CC4=C(C(C3=C(O)[C@@]21O)=O)C(O)=C(NC(CNC(C)(C)C)=O)C=C4N(C)C)N.Cl

Molecular Formula

C29H40ClN5O8

Molecular Weight

622.11

References & Citations

[1]Jitkova Y, et al. A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity. PLoS One. 2014 May 28;9 (5) :e95281.|[2]Falagas ME, et al. Activity of TP-6076 against carbapenem-resistant Acinetobacter baumannii isolates collected from inpatients in Greek hospitals. Int J Antimicrob Agents. 2018 Aug;52 (2) :269-271.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Ann Lab Med. 2021 May 1;41 (3) :293-301.|Emerg Microbes Infect. 2024 Dec;13 (1) :2321981.|Adv Ther (Weinh) . 2024 Jan 12.|Anim Dis. 2021;1 (1) :26.|Ann Clin Microbiol Antimicrob. 2024 Aug 20;23 (1) :73.|Antimicrob Agents Chemother. 2019 May 24;63 (6) . pii: e00470-19.|Antimicrob Agents Chemother. 2023 Feb 16;67 (2) :e0145922.|Antimicrob Agents Chemother. 2024 Mar 6;68 (3) :e0112023.|Antimicrob Agents Chemother. 2024 Oct 29:e0094524.|Antimicrob Agents Chemother. 2025 May 23:e0024925.|Authorea. 2025 Sep 17.|Biomed Pharmacother. 2023 Dec 31:169:115856.|Cell Rep. 2025 Nov 25;44 (11) :116496.|Cell. 2025 May 15;188 (10) :2757-2777.e22.|Clin Exp Pharmacol Physiol. 2023 Jul;50 (7) :604-609.|Cureus. 2024 Dec 1;16 (12) :e74917.|EBioMedicine. 2022 Apr;78:103943.|Infect Drug Resist. 2020 Jul 28;13:2617-2629.|Infect Drug Resist. 2021 Jun 30;14:2499-2507.|Infect Drug Resist. 2023 Apr 17:16:2271-2279.|Infect Drug Resist. 2025 Oct 4:18:5239-5247.|Infect Genet Evol. 2025 Sep:133:105780.|Int J Antimicrob Agents. 2018 Aug;52 (2) :269-271.|Int J Antimicrob Agents. 2025 Jun 9:107551.|J Antibiot (Tokyo) . 2022 Aug;75 (8) :463-471.|J Antimicrob Chemother. 2025 Apr 10:dkaf105.|J Appl Microbiol. 2025 Apr 17:lxaf093.|Microb Pathog. 2020 Dec;149:104502.|Microbiol Spectr. 2023 Feb 14;11 (1) :e0323822.|Microbiol Spectr. 2023 Jun 15;11 (3) :e0071823.|Microbiol Spectr. 2025 Mar 19:e0134424.|Microorganisms. 2024 Mar 13;12 (3) :575.|Nat Commun. 2022 Mar 2;13 (1) :1116.|Nat Commun. 2024 Jun 28;15 (1) :5481.|Naunyn Schmiedebergs Arch Pharmacol. 2025 Oct 29.|SLAS Discov. 2020 Sep;25 (8) :895-905.|Vet Microbiol. 2024 May:292:110046.|World J Microbiol Biotechnol. 2024 Jun 6;40 (8) :233.

Chemical Information

Tigecycline hydrochloride

CAS Number	197654-04-9
PubChem CID	54749425
IUPAC Name	(4S,4aS,5aR,12aR)-9-[[2-(tert-butylamino)acetyl]amino]-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride
Molecular Formula	C29H40ClN5O8
Molecular Weight	622.1
Topological Polar Surface Area	206
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	7
Heavy Atom Count	43
Formal Charge	0
Complexity	1240

SMILES

CC(C)(C)NCC(=O)NC1=CC(=C2C[C@H]3C[C@H]4[C@@H](C(=O)C(=C([C@]4(C(=O)C3=C(C2=C1O)O)O)O)C(=O)N)N(C)C)N(C)C.Cl

InChI

InChI=1S/C29H39N5O8.ClH/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36;/h10,12,14,21,31,36-37,40,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35);1H/t12-,14-,21-,29-;/m0./s1

InChIKey

FHFADVHACRVXAT-KXLOKULZSA-N

Chemical Structure

2D Structure

CAS: 197654-04-9

CID: 54749425

Formula: C29H40ClN5O8

MW: 622.1

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	622.1
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	7
Exact Mass	621.2565409
Monoisotopic Mass	621.2565409
Topological Polar Surface Area	206 Å²
Heavy Atom Count	43
Formal Charge	0
Complexity	1240
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

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Catalog	Name
B1219-500	Tigecycline hydrochloride
CS-O-52133	Tigecycline Epimer Hydrochloride
A5226-5	Tigecycline

Tigecycline (hydrochloride)

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