Tigecycline

• UNSPSC Description:

  Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic. The mean inhibitory concentration (MIC) of Tigecycline for E. coli (MG1655 strain) is approximately 125 ng/mL[1]. MIC50 and MIC90 are 1 and 2 mg/L for Acinetobacter baumannii (A. baumannii), respectively[2].

• Target Antigen:

  Antibiotic; Autophagy; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Autophagy

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Tigecycline.html

• Purity:

  99.95

• Solubility:

  DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 8.33 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@]3([H])CC4=C(C(C3=C(O)[C@@]21O)=O)C(O)=C(NC(CNC(C)(C)C)=O)C=C4N(C)C)N

• Molecular Weight:

  585.65

• References & Citations:

  [1]Jitkova Y, et al. A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity. PLoS One. 2014 May 28;9(5):e95281.|[2]Falagas ME, et al. Activity of TP-6076 against carbapenem-resistant Acinetobacter baumannii isolates collected from inpatients in Greek hospitals. Int J Antimicrob Agents. 2018 Aug;52(2):269-271.Adv Ther (Weinh). 2024 Jan 12.|Animal Diseases. 02 November 2021.|Ann Clin Microbiol Antimicrob. 2024 Aug 20;23(1):73.|Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00470-19.|Antimicrob Agents Chemother. 2023 Jan 23;e0145922.|Antimicrob Agents Chemother. 2024 Jan 30:e0112023.|Biomed Pharmacother. 2023 Nov 8:115856.|Clin Exp Pharmacol Physiol. 2023 Apr 22.|EBioMedicine. 2022 Apr;78:103943.|Infect Drug Resist. 2020 Jul 28;13:2617-2629.|Infect Drug Resist. 2021 Jun 30;14:2499-2507.|Infect Drug Resist. 2023 Apr 17.|Int J Antimicrob Agents. 2018 Aug;52(2):269-271.|J Antibiot (Tokyo). 2022 Jun 27.|Microb Pathog. 2020 Dec;149:104502.|Microbiol Spectr. 2022 Dec 8;e0323822.|Microbiol Spectr. 2023 May 4;e0071823.|Microorganisms. 2024 Mar 13, 12(3), 575.|Nat Commun. 2022 Mar 2;13(1):1116.|Nat Commun. 2024 Jun 28;15(1):5481.|SLAS Discov. 2020 Sep;25(8):895-905.|Vet Microbiol. 2024 May, 292, 110046.|World J Microbiol Biotechnol. 2024 Jun 6;40(8):233.|Ann Lab Med. 2021 May 1;41(3):293-301.|Emerg Microbes Infect. 2024 Dec;13(1):2321981.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  220620-09-7