CV-159

• Description :

  CV-159 is a unique dihydropyridine Ca2+ antagonist with an anti-calmodulin (CaM) action, and has antiinflammatory activities.

• UNSPSC :

  12352005

• Target :

  Calmodulin

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/CV-159.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=C(C)NC(C)=C(C(OCCCCCCOC2=NNC(C3=CC=CC=C3)=C2)=O)C1C4=CC=CC([N+]([O-])=O)=C4)OC

• Molecular Formula :

  C31H34N4O7

• Molecular Weight :

  574.62

• References & Citations :

  [1]Usui T, et al. Mechanisms underlying the anti-inflammatory effects of the Ca2+/calmodulin antagonist CV-159 in cultured vascular smooth muscle cells. J Pharmacol Sci. 2010;113 (3) :214-23. Epub 2010 Jun 16.|[2]Usui T, et al. CV-159, a unique dihydropyridine derivative, prevents TNF-induced inflammatory responses in human umbilical vein endothelial cells. J Pharmacol Sci. 2010;113 (2) :182-91. Epub 2010 May 19.|[3]Miyazaki H, et al. Neuroprotective effects of a dihydropyridine derivative, 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarbox ylic acid methyl 6- (5-phenyl-3-pyrazolyloxy) hexyl ester (CV-159), on rat ischemic brain injury. Life Sci. 1999;64 (10) :869-78.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [86384-98-7]