CV-4-26

• Description :

  CV-4-26 (Compound 22) is a covalent inhibitor of TEAD. CV-4-26 inhibits YAP/TEAD-based transcription, leading to the reduction of CTGF and CYR61 expression. CV-4-26 inhibits Huh7 and HepG2 cell colony formation, induces cell cycle arrest, and apoptosis. CV-4-26 shows antitumor activity against hepatocellular carcinoma (HCC) and hepatoblastoma (HB) [1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; YAP

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Stem Cell/Wnt

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cv-4-26.html

• Smiles :

  O=C(CCl)C1=CNC2=C1C=C(OCC3=CC=CC(C(F)(F)F)=C3)C(Cl)=C2

• Molecular Formula :

  C18H12Cl2F3NO2

• Molecular Weight :

  402.19

• References & Citations :

  [1]Zhou C, et al. Development of Novel Indole-Based Covalent Inhibitors of TEAD as Potential Antiliver Cancer Agents. J Med Chem. 2024 Sep 26;67 (18) :16270-16295.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  YAP/TAZ-TEAD