CV-4-26

• Description:

  CV-4-26 (Compound 22) is a covalent inhibitor of TEAD. CV-4-26 inhibits YAP/TEAD-based transcription, leading to the reduction of CTGF and CYR61 expression. CV-4-26 inhibits Huh7 and HepG2 cell colony formation, induces cell cycle arrest, and apoptosis. CV-4-26 shows antitumor activity against hepatocellular carcinoma (HCC) and hepatoblastoma (HB) [1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; YAP

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Stem Cell/Wnt

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cv-4-26.html

• Smiles:

  O=C (CCl) C1=CNC2=C1C=C (OCC3=CC=CC (C (F) (F) F) =C3) C (Cl) =C2

• Molecular Formula:

  C18H12Cl2F3NO2

• Molecular Weight:

  402.19

• References & Citations:

  [1]Zhou C, et al. Development of Novel Indole-Based Covalent Inhibitors of TEAD as Potential Antiliver Cancer Agents. J Med Chem. 2024 Sep 26;67 (18) :16270-16295.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  YAP/TAZ-TEAD