RegisterLogin

CV-4-26

CAT: 804-HY-168085Size: 1 EachDry Ice: NoHazardous: No
1 EachSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
CV-4-26 (Compound 22) is a covalent inhibitor of TEAD. CV-4-26 inhibits YAP/TEAD-based transcription, leading to the reduction of CTGF and CYR61 expression. CV-4-26 inhibits Huh7 and HepG2 cell colony formation, induces cell cycle arrest, and apoptosis. CV-4-26 shows antitumor activity against hepatocellular carcinoma (HCC) and hepatoblastoma (HB) [1].
UNSPSC
12352005
Target
Apoptosis; YAP
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cv-4-26.html
Smiles
O=C(CCl)C1=CNC2=C1C=C(OCC3=CC=CC(C(F)(F)F)=C3)C(Cl)=C2
Molecular Formula
C18H12Cl2F3NO2
Molecular Weight
402.19
References & Citations
[1]Zhou C, et al. Development of Novel Indole-Based Covalent Inhibitors of TEAD as Potential Antiliver Cancer Agents. J Med Chem. 2024 Sep 26;67 (18) :16270-16295.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
YAP/TAZ-TEAD

Related Products

CatalogName
HY-19064CV-6504
HY-19025CV-159
HY-106062CV 3988
HY-106797CV 3611
HY-109897-01CV-6209
HY-162815PROTAC SMARCA2/4-degrader-26
HY-133967-01(25R) -26-Hydroxycholest-4-en-3-one
HY-160166TRK-IN-26
HY-149332α-Glucosidase-IN-26
HY-163526-01STAT3-IN-26

Alternative Products

CatalogName
T200708-01CV-4-26
445179-01CV-3988
MBS5813861CV 6504
TRC-C856003-25MGCV-3988
MBS5776823CV-6209
sc-207461ACV-6209
CHR3269Kinesis Inline CV Cartridge; for CV-3010
007133CV-6209
255057CV 1808
MBS3600036-01CV-6209

Popular Products