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EGFR-IN-159

CAT: 0804-HY-172621Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172621Size:1 Each
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Description
EGFR-IN-159 (compound 12), a dihydropyrimidine, is a potent EGFR inhibitor with an IC50 value of 29.00 nM. EGFR-IN-159 exhibits dose-dependent inhibition against EGFR and HER2. EGFR-IN-159 shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 has no BBB permeation. EGFR-IN-159 shows appreciable anti-cancer activity[1].
CAS Number
2055746-08-0
UNSPSC
12352005
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
OC1=C(OCC)C=C(C2C(C(NC3=C(OC)C=CC=C3)=O)=C(C)NC(N2)=O)C=C1
Molecular Formula
C21H23N3O5
Molecular Weight
397.42
References & Citations
[1]Ruby Mariam Raju, et al. Computational and experimental approach to develop novel Biginelli dihydropyrimidines as EGFR inhibitors against breast cancer. Journal of Molecular Structure, 2025, 1328: 141226.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; ErbB2/HER2

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