CliMB-325

CAT: 0804-HY-179211Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-179211Size:1 Each

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Description

CliMB-325 is an HSP90 inhibitor that can induce MHC-I (EC50 = 498 nM) expression on the surface of CT26 murine colorectal cancer cells. CliMB-325 enhances T cell activation and exhibits lower toxicity. CliMB-325 can be used for the study of colorectal cancer[1].

UNSPSC

12352005

Target

HSP; MHC

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

ClC1=C2N=CN(C2=NC(N)=N1)CC3=CN(N=N3)C4=CC=C(C=C4C#N)Cl

Molecular Formula

C15H9Cl2N9

Molecular Weight

386.20

References & Citations

[1]Newkirk SE, et al. Small Molecule Modulation of MHC-I Surface Expression: A Click Chemistry-Based Discovery Approach. J Med Chem. 2025 Nov 13;68 (21) :22301-22311.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HSP90; MHC I

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464799-01	ROC 325
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T16777-01	ROC-325
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CliMB-325

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