CliMB-325

• Description:

  CliMB-325 is an HSP90 inhibitor that can induce MHC-I (EC50 = 498 nM) expression on the surface of CT26 murine colorectal cancer cells. CliMB-325 enhances T cell activation and exhibits lower toxicity. CliMB-325 can be used for the study of colorectal cancer[1].

• UNSPSC:

  12352005

• Target:

  HSP; MHC

• Related Pathways:

  Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Smiles:

  ClC1=C2N=CN(C2=NC(N)=N1)CC3=CN(N=N3)C4=CC=C(C=C4C#N)Cl

• Molecular Formula:

  C15H9Cl2N9

• Molecular Weight:

  386.20

• References & Citations:

  [1]Newkirk SE, et al. Small Molecule Modulation of MHC-I Surface Expression: A Click Chemistry-Based Discovery Approach. J Med Chem. 2025 Nov 13;68 (21) :22301-22311.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HSP90; MHC I