NAS-181

• Description :

  NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an Ki value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions[1].

• UNSPSC :

  12352005

• Target :

  5-HT Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/nas-181.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CS(=O)(O)=O.[C@H]1(COC2=C3C(C=C(CN4CCOCC4)CO3)=CC=C2)CNCCO1

• Molecular Formula :

  C20H30N2O7S

• Molecular Weight :

  442.53

• References & Citations :

  [1]Berg S, et al. (R) - (+) -2-[[[3- (Morpholinomethyl) -2H-chromen-8-yl]oxy]methyl] morpholine methanesulfonate: a new selective rat 5-hydroxytryptamine1B receptor antagonist. J Med Chem. 1998 May 21;41 (11) :1934-42.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT1 Receptor

• Citation 01 :

  BioRxiv. 2025 August 23.|Nat Neurosci. 2022 Dec;25 (12) :1651-1663.|Transl Neurodegener. 2024 Jul 24;13 (1) :34.

• CAS Number :

  [205242-62-2]